How stress is essentially changing our memory, according to a research
In order to restore proper memory specificity in individuals with post-traumatic stress disorder (PTSD), researchers at The Hospital for Sick Children (SickKids) discovered that stress changes how our brain encodes and recovers negative memories.
Your brain may link your next presentation to that one bad and unpleasant experience, which could make you anxious the next time you have to give a presentation. One memory is linked to this kind of stress. A phenomenon known as stress-induced unpleasant memory generalization occurs when stress from traumatic events, such as violence or generalized anxiety disorder, spreads far beyond the initial incident. For example, fireworks or automobile backfires might cause fearful memories that seem unconnected and ruin your entire day. It can have far more detrimental effects in the case of PTSD.
Stress is Essential in these days:
The neurobiological mechanisms underlying stress-induced aversive memory generalization are identified by Drs. Sheena Josselyn and Paul Frankland, Senior Scientists in the Neurosciences & Mental Health program, in a study published in Cell. They also highlight an intervention that may help PTSD sufferers regain appropriate memory specificity.
In order to restore proper memory specificity in individuals with post-traumatic stress disorder (PTSD), researchers at The Hospital for Sick Children (SickKids) discovered that stress changes how our brain encodes and recovers negative memories.
By blocking endocannabinoid receptors on interneurons, the study team, along with their colleague Dr. Matthew Hill from the University of Calgary Hotchkiss Brain Institute, was able to restrict stress-induced painful memory generalization to the relevant memory.
In order to produce a non-specific scared memory that may be triggered by unrelated safe conditions, much like PTSD manifests in people, the study team used a preclinical model in which individuals were exposed to an acute but safe stress prior to an aversive event.
The group then looked at the subject’s memory engrams, which are brain representations of memories that were first created by the SickKids Josselyn and Frankland labs.
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